Passive Protection of Mice Against Intraperitoneally Injected Vibrio cholerae by γG and γM Antibody

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Passive protection of mice against intraperitoneally injected Vibrio cholerae by G and M antibody.

Fractions of rabbit anti-Vibrio cholerae serum containing gammaG antibodies were compared with fractions containing gammaM antibodies for their ability to protect mice against lethal infection resulting from the intraperitoneal injection of organisms suspended in mucin. About twice as much gammaG as gammaM (estimated by quantitative precipitation) was required to protect against approximately 1...

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Immunity to Vibrio cholerae in the mouse. I. Passive protection of newborn mice.

Mice were immunized subcutaneously with either killed cells or a ribosome-containing fraction (RF) obtained from Vibrio cholerae Ogawa 41. At appropriate time intervals, these mice or their progeny were challenged with uniformly lethal doses of Ogawa or Inaba serotype. Half of the offspring born to mice immunized with 20 mug of RF were protected against homologous challenge at 7.5 weeks of age,...

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Both specific polyclonal antiserum and monoclonal antibodies against mannose-binding hemagglutinin fimbriae of Vibrio cholerae (mannose-sensitive hemagglutinin [MSHA]) were shown to protect against experimental cholera caused by vibrios of the El Tor biotype in the infant mouse and in the rabbit intestinal loop models. MSHA-specific Fab immunoglobulin fragments were also protective. No protecti...

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production of antibody raised against lipopolysaccharide (lps) of vibrio cholerae non-o1

background: cholera, an infectious disease caused by vibrio cholerae , is primarily transmitted by ingestion of contaminated food or water. in severe cases, cholera may lead to severe dehydration, metabolic acidosis, and ultimately, hypovolemic shock and death.   methods: in this study v.cholerae non-o1 was cultured in suitable media. lps was extracted from the surface of  bacteria by hot pheno...

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ژورنال

عنوان ژورنال: Infection and Immunity

سال: 1971

ISSN: 0019-9567,1098-5522

DOI: 10.1128/iai.4.5.589-592.1971